Statistical Modelling 6 (2006), 322
Bayesian semi-parametric accelerated failure time model for paired
doubly interval-censored data
Arnošt Komárek
Biostatistical Center,
Katholieke Universiteit Leuven,
Kapucijnenvoer 35,
B3000 Leuven
Belgium.
eMail: arnost.komarek@med.kuleuven.be
Emmanuel Lesaffre
Biostatistical Center,
Katholieke Universiteit Leuven.
Abstract:
In this paper, we propose a methodology which a) evaluates the effect
of covariates on doubly interval-censored paired responses, b) is
based on minimal parametric assumptions concerning the distributional
parts of the model and c) evaluates the association between the two
responses of the pair. Our methodology tackles three research questions
arising from the Signal Tandmobiel® project, a
prospective Flemish (Belgian) longitudinal dental study. The research
questions are 1) What is the effect of baseline covariates on the
time-to-caries of the permanent right first molars? 2) Is the effect
of the covariates the same for the upper and lower teeth? 3) What is
the association between the times-to-caries on the upper and lower
teeth? Time-to-caries is defined as the difference of two
interval-censored observations, caries time and emergence time, and
hence it is a doubly interval-censored response. We suggest using an
accelerated failure time model with a bivariate smooth error
distribution being a mixture of bivariate normal components defined
on a fine fixed grid. To deal with the problem of doubly interval
censoring, we use Bayesian methodology and Markov chain Monte Carlo
sampling.
Keywords:
density smoothing; Gaussian Markov random field;
Markov chain Monte Carlo; regression; survival data
Downloads:
Data and R code
in zipped archive
IMPORTANT NOTICE: It is possible to use these data for your
research work under the condition that each manuscript is first
approved by
Prof. Emmanuel Lesaffre
Biostatistical Centre Katholieke Universiteit Leuven
Kapucijnenvoer 35
B-3000 Leuven
Belgium
eMail: emmanuel.lesaffre@med.kuleuven.be
R and R package bayesSurv are available for download at
http://cran.r-project.org.
back